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相关概念视频

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
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通过表面去矿化,固态酸与骨组织之间具有强大的粘附性.

Shichao Xie1, Masahiro Okada2, Haruyuki Aoyagi1

  • 1Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan.

Bioactive materials
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一种新型的酸 (HAp) 骨粘合剂通过去矿化骨表面来证明强大的固定作用. 这一策略提高了生物医学应用的生物相容性和机械强度.

关键词:
原蛋白是一种原蛋白.没有矿物质的骨头.补水 补水 水分 补水 补水氧亚帕提特是一种氧亚帕提特.固态粘合剂是一种固态粘合剂.

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科学领域:

  • 生物材料科学 生物材料科学
  • 整形外科手术 整形外科手术
  • 组织工程是组织工程.

背景情况:

  • 目前的骨粘合剂往往表现出不够的机械强度,长期稳定性和生物相容性.
  • 开发先进的骨粘合剂对于改善骨科手术和骨缺陷修复至关重要.

研究的目的:

  • 设计和评估一种新的固态酸 (HAp) 粘合剂,与骨表面去矿化相结合,以增强骨粘合力.
  • 研究不同脱矿剂对粘合性质和稳定性的影响.

主要方法:

  • 固态HAp粘合剂的合成和特征.
  • 使用酸 (H3PO4) 或乙烯基胺酸 (EDTA) 进行皮层骨的去矿化.
  • 测量了剪切粘附强度,并对老鼠的体内固定进行了评估.

主要成果:

  • 在去矿物质化骨表面上实现了有效的粘附,但在非去矿物质化骨头上没有.
  • 与H3PO4处理的样本相比,EDTA处理的样本显示出明显更高的剪切粘附强度 (10小时238.4kPa) 与H3PO4处理的样本相比 (1小时102.9kPa).
  • EDTA保留了原结构和水含量,增强了粘附性; in vivo稳定固定得到证实.

结论:

  • 表面去矿化是固态HAp与骨强烈粘附的关键,通过暴露与水胀的原体.
  • 粘附强度受到非矿物化层结构变化的影响.
  • HAp粘合剂在体内提供稳定的固定,显示了骨生物医学应用的潜力.