轻度COVID-19引起的炎症导致 rhesus macaques 持续的神经和行为变化
Tomas R Wiche Salinas1, Sienna Freeman1, Rebecca Richardson1
1Emory National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta GA 30329, USA.
Research square
|December 11, 2025
概括
轻度的COVID-19可能会导致长期的神经认知问题,如感官改变和认知灵活性. 这项对的研究将这些持续的症状与最初的炎症反应和大脑变化联系起来.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- SARS-CoV-2 感染 (PASC) 的急性后续症状在轻度 COVID-19 后呈现持续症状.
- 驱动PASC的机制,特别是神经认知影响,仍然不太了解.
- 由于对PASC病原体的理解存在差距,存在有限的治疗选择.
研究的目的:
- 为了研究SARS-CoV-2感染引起的炎症的神经认知效应.
- 探索急性炎症反应与长期神经认知后果之间的联系.
- 用一个非人类灵长类动物模型来研究PASC相关的神经炎症.
主要方法:
- 十个成年 rhesus (5 个雌性,5 个雄性) 感染了SARS-CoV-2 (2019-noCoV/USA-WA1/2020菌株).
- 在感染之前,感染期间和感染后的3-4个月内,对神经认知和生理变化进行了监测.
- 在感染后,对脑组织进行了微质激活的分析.
主要成果:
- 在感染后的3个月内,在味觉,嗅觉和认知灵活性方面表现出持续的缺陷.
- 雌性鱼经历了睡眠障碍,增加了压力和自主功能受损.
- 神经认知变化与急性细胞因子反应和大脑中微质激活增加相关.
结论:
- 轻微的SARS-CoV-2感染可能导致持久的神经认知变化.
- 对SARS-CoV-2的急性炎症反应与持续的神经认知缺陷有关.
- 针对急性炎症途径可能为PASC提供治疗策略.
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