在越南人群中,代谢功能障碍相关的脂肪性肝病 (MALSD) 的预测因素
Anh Gia Pham1, An Vu-Khanh Le1, Yen Thi-Hai Pham2
1Viet Duc University Hospital.
Research square
|December 11, 2025
概括
在越南成年人中,代谢功能障碍相关的脂肪性肝病 (MASLD) 的预测因素包括BMI,糖尿病,AST,GGT,INR和肝硬度测量. 这些发现有助于在这一群体中对MASLD的风险分层和管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,导致肝癌发病率.
- 亚洲人群中,特别是越南人群中,MASLD的预测因素的理解较少.
研究的目的:
- 确定越南人口中MASLD的关键预测因素.
- 为越南MASLD的风险分层和治疗管理提供证据.
主要方法:
- 一项基于医院的病例控制研究,涉及100名MASLD患者和119名健康对照.
- 使用无条件逻辑回归来确定MASLD预测器的几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 重要的预测因素包括体重指数 (BMI),糖尿病,AST,GT,INR,kPa和CAP分数.
- 较高的BMI (>23 kg/m2),糖尿病,升高的AST (≥40),升高的GGT (≥55738),INR (>1.0),kPa (>8.2) 和CAP得分 (>257.1) 与增加的MASLD风险有关.
- 心脏代谢因素,血小板计数,ALT,白蛋白,胆固醇和甘油三与MASLD风险没有显著关联.
结论:
- 肝硬度测量 (kPa和CAP分数) 是越南人口中MASLD的关键预测因素,与BMI,糖尿病,AST和GGT等临床因素一起.
- 这项研究为MASLD风险分层和风险管理提供了针对越南个人的新见解.
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