在加利福尼亚州教师研究中,诊断前娱乐性体力活动和肺癌死亡率
Emily L Cauble1, Mia Blanchard2, Peggy Reynolds3
1City of Hope.
Research square
|December 11, 2025
概括
身体活动 (PA) 可能会影响肺癌存活率,但吸烟状态是关键因素. 适度的PA可能会降低前吸烟者的死亡风险,而艰苦的PA会增加目前吸烟者的风险.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 身体活动 (PA) 与肺癌死亡率的降低有关,但研究结果各不相同.
- 了解PA,吸烟和肺癌风险的相互作用至关重要.
研究的目的:
- 调查诊断前PA水平与肺癌死亡率之间的关联.
- 探索时间变化和运动变化的PA如何影响结果.
- 澄清行为风险因素在肺癌死亡率中的作用.
主要方法:
- 来自加利福尼亚州教师研究队列的1,768名被诊断患有肺癌的妇女的分析 (1995-2019).
- 评估一生和最近的诊断前的身体活动.
- 使用多变量考克斯回归来估计危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在各种PA指标中观察到类似的肺癌死亡风险.
- 较高的中度PA与前吸烟者的较低死亡率相关.
- 艰苦的PA与当前吸烟者的死亡率增加有关,但在从未吸烟的人群中显示出保护作用.
结论:
- 吸烟状态显著改变了PA和肺癌死亡率之间的关系.
- 假设艰苦的PA可能会使目前吸烟者的吸烟引起的炎症恶化.
- 需要进一步的研究来阐明这些观察到的关联背后的机制.
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