在患有非小细胞肺癌的患者中,对术后深静脉血栓的诺莫格拉姆预测模型的评估
Pengyu Ji1, Zhenping Guo1, Yong Wang1
1Thoracic and Cardiovascular Surgery Department, Ordos Central Hospital, Ordos, China.
Translational cancer research
|December 11, 2025
概括
一种新型的诺姆图准确地预测了手术后非小细胞肺癌 (NSCLC) 患者的深静脉血栓塞 (DVT) 风险. 该工具使用常规临床数据指导有针对性的预防策略.
科学领域:
- 在瘤学瘤学.
- 血管外科 血管外科
- 医疗信息学 医疗信息学
背景情况:
- 非小细胞肺癌 (NSCLC) 患者面临术后深静脉血栓形成 (DVT) 的高风险.
- 在这些患者中,DVT显著复杂化了康复和生存.
- 需要预测工具来管理NSCLC手术中的DVT风险.
研究的目的:
- 开发和验证用于预测NSCLC患者手术后DVT的诺米克图.
- 在这个人群中确定DVT的独立风险因素.
- 创建一个临床上适用于风险分层的工具.
主要方法:
- 对260名NSCLC患者 (120名患有DVT,140名没有) 的回顾性分析.
- 后勤回归分析以确定DVT预测因子.
- 在174名患者中进行诺莫格拉姆构建和外部验证.
主要成果:
- 确定了四个独立的预测因素:老年年龄,糖尿病,腺癌组织学和III期病理学.
- 诺米图表显示了高的预测准确性 (AUC 0.900导出,0.903验证).
- 该模型展示了良好的校准和歧视.
结论:
- 一个经过验证的nomogram准确地预测NSCLC患者的DVT风险.
- 在使用常规的临床参数的情况下,名图表的性能优于现有的工具.
- 这种工具有助于分层血栓预防,特别是在资源有限的环境中.
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