胰腺的巨介导的代谢失调:从肥胖的见解
Ke-Ran Chen1, Ze-Yu Chen1, Fei-Yi Liu1
1Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
World journal of biological chemistry
|December 11, 2025
概括
肥胖会通过巨细胞触发胰腺损伤,促进炎症和损害胰岛素分泌. 针对这些免疫细胞提供了一种潜在的策略,以对抗肥胖的代谢功能障碍.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
- 胰腺生物学 胰腺生物学
背景情况:
- 肥胖是代谢功能障碍的重要驱动因素,对胰腺健康有深远的影响.
- 巨细胞是参与调节胰腺内炎症和代谢的核心免疫细胞.
- 肥胖引起的胰腺损伤包括巨细胞的透,极化和炎症性细胞因子的分泌.
研究的目的:
- 阐明胰腺巨细胞在与肥胖相关的代谢功能障碍中的作用.
- 研究巨细胞在肥胖条件下损害胰腺β细胞功能的机制.
- 探索潜在的治疗策略,针对代谢障碍的巨细胞.
主要方法:
- 在肥胖胰腺组织中分析巨细胞透和极化.
- 胰腺巨细胞对炎症性细胞因子分泌 (CCL2,TGF-β) 的研究.
- 在巨细胞激活中检查SUCLA2-HIF-1α轴和mTORC1/PD-1通路.
- 评估涉及微RNA (miR-155,miR-30a) 的外体介导器官间通信.
主要成果:
- 亲炎性M1巨细胞分泌CCL2和TGF-β,破坏β细胞功能和胰岛素分泌.
- 抗炎M2巨细胞在慢性代谢压力下可能导致纤维化.
- 由高脂肪饮食激活的胰腺巨细胞通过特定的分子通路损害β细胞功能,创建代谢-免疫抑制循环.
- 外体细胞调解器官间的沟通,这与胰腺代谢健康有关.
结论:
- 胰腺巨细胞是肥胖引起的代谢功能障碍和胰腺损伤的关键媒介.
- 向巨细胞激活,例如用SUCLA2抑制剂,可以改善代谢失调.
- 外体介导通信为与肥胖相关的胰腺疾病的多系统协同治疗提供了新的治疗途径.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
645
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
645
01:20Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:36Carbohydrate Metabolism
13.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.7K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
159
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
159
01:27Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
2.1K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
2.1K