使用心声扫描检查的男性和女性的左心室质量增加和死亡
David Playford1,2, Geoff Strange1,3,4, Majo Joseph5
1Institute for Health Research, University of Notre Dame Australia Fremantle Western Australia Australia.
Journal of the American Heart Association
|December 11, 2025
概括
左心室质量指数 (LVMi) 的新性别分层值显示,即使没有诊断的左心室缩 (LVH),许多人死亡风险也很高. 这些发现表明需要积极的临床管理.
科学领域:
- 心脏病学 心脏病学
- 医学诊断 医学诊断 医学诊断
- 公共卫生 公共卫生
背景情况:
- 左心室缩症 (LVH) 的分类依赖于左心室质量指数 (LVMi).
- 现有的LVH标准可能不准确地反映不同性别的增量死亡风险.
- 这项研究解决了与死亡率相关的性别特异性LVMi切线的需求.
研究的目的:
- 为了生成和外部验证性别分层的左心室质量指数 (LVMi) 切断值.
- 为了将这些切断与增加的5年死亡风险相关联.
- 为了识别风险较高的个体,尽管没有传统的LVH诊断.
主要方法:
- 利用了澳大利亚大型心声回声数据库 (155,668名男性,147,880名女性).
- 产生了与增加5年死亡率相关的性别特定的LVMi值.
- 在一个独立的美国医疗保险相关的心声回声队列中验证了这些值.
主要成果:
- 与传统标准相比,在男性 (≥88 g/m2) 和女性 (≥82 g/m2) 两种情况下都确定了较低的LVMi值,用于增加死亡风险.
- 较高的LVMi水平,甚至低于传统的LVH定义,与明显更高的5年死亡风险相关 (例如,男性68%更高,女性81%更高).
- 这些发现在美国验证队列中得到证实,包括没有显著并发症的个人.
结论:
- 很大一部分男性和女性表现出与死亡风险增加相关的LVMi水平,独立于正式的LVH诊断.
- 这些人可能会从更早的识别和更积极的临床管理策略中受益.
- 性别特定的LVMi值对于准确的风险分层和改善患者结果至关重要.
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