精神分裂症的记忆过程:伴随着物质使用障碍的并发症的影响
Alvaro Gonzalez-Sanchez1,2, José Francisco Navarro3, Ana Adan1,2,4
1Department of Clinical Psychology and Psychobiology, School of Psychology, https://ror.org/021018s57University of Barcelona, Barcelona, Spain.
Irish journal of psychological medicine
|December 11, 2025
概括
精神分裂症患者表现出明显的口头记忆缺陷,特别是在编码和存储方面,与那些仅患有物质使用障碍的人相比. 与物质使用障碍的并发症会微妙地恶化这些记忆障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 在精神分裂症谱系障碍中,口头记忆缺陷很常见.
- 伴随性物质使用障碍对精神分裂症口头记忆的影响需要进一步澄清.
研究的目的:
- 在三个组中比较口头记忆编码,存储和检索:精神分裂症 (SZ),精神分裂症与物质使用障碍 (SZ+) 和仅物质使用障碍 (SUD).
- 测试SZ+组表现出比SZ组更大的口头记忆障碍的假设.
主要方法:
- 总共有294名男性患者使用Rey听力语言学习测试 (RAVLT) 进行了评估.
- 这些组包括SZ (n=72),SZ+ (n=72) 和SUD (n=150).
- 在ANCOVA/MANCOVA分析中,对患病前智商进行了控制,以比较记忆过程中的群体差异.
主要成果:
- 在大多数RAVLT测量中发现了显著的群体差异,不包括检索.
- 与SUD组相比,SZ和SZ+组都表现出明显的口头记忆障碍.
- 与SZ集团相比,SZ+集团在编码和整合方面表现微妙,但显著,表现更差.
结论:
- 语言记忆障碍是精神分裂症谱系障碍的核心特征,无论是物质使用障碍的并发症.
- 虽然伴随性物质使用障碍在精神分裂症中微妙地加剧了记忆缺陷,但SZ和SZ+组之间的差异在所有措施上都没有统计学意义.
- 需要进一步的研究,以探索临床变量和调节者影响共患病对精神分裂症记忆的影响.
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