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下微生物群组成与年轻成年人密码性缺血性中风的风险,严重程度和结果的关联

Muhammed Manzoor^1,2, Svetislav Zaric³, Anbo Dong³

¹Department of Oral and Maxillofacial Diseases University of Helsinki Finland.

Journal of the American Heart Association

|December 11, 2025

概括

在患有密码性缺血性中风 (CIS) 的患者中,下微生物群的组成不同. 特定的口腔细菌,如T. denticola,与增加CIS风险有关,这表明口腔健康可能会影响中风预防.

科学领域:

微生物学微生物学
神经学神经学
口腔健康口腔健康

背景情况:

口腔和肠道失调症与中风的发展和结果有关.
下微生物群在密码性缺血性中风 (CIS) 中的特定作用尚不清楚.

研究的目的:

为了比较CIS患者和对照者之间的下微生物群.
确定与CIS相关的特定微生物群,中风严重程度和临床结果.

主要方法:

一项多中心病例控制研究,涉及272名参与者 (134名CIS患者,138名对照).
使用16S rRNA基因测序分析的下样本.
用国家卫生研究院中风评分表来评估中风的严重程度.

主要成果:

在CIS患者和对照人群之间,β多样性的显著差异.
在患者中增加了*Spirochaetota*和*Treponema*的丰度.
在患者中减少了*Pseudomonadota*,*Veillonella*和*Capnocytophaga*的丰度.
*T. denticola* 丰度与增加的CIS风险相关 (OR 1.002,P=0.021经调整后).

结论:

下微生物群的组成与CIS有关.
研究结果表明,口腔健康和中风病理生理学之间存在潜在联系.
口腔微生物群可能是CIS预防和改善结果的可修改目标.

关键词:

16S rRNA 基因测序的基因测序修改后的排名级别表.脑中风的严重程度中风的严重程度在 subgingival 微生物组中.年轻开始的中风.

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