在COVID-19大流行期间,华法林转换为里瓦洛克萨班的血栓形成和出血结果
C-Y Wang1, E Schapkaitz1, S Louw1
1Division of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
|December 11, 2025
概括
在COVID-19大流行期间,从华法林转换为里瓦洛克萨班的患者表现出类似的出血和血栓形成率. 这项研究提供了在公共卫生危机期间管理抗凝血药物的见解.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 由于COVID-19大流行,患者管理需要改变,包括切换抗凝治疗.
- 华法林转换为里瓦洛克萨班的方法是为了降低COVID-19传播风险.
研究的目的:
- 为了评估COVID-19大流行期间从华法林转换为里瓦洛克萨班的患者的血栓形成和出血结果.
- 为在未来的公共卫生紧急情况中管理抗凝血剂提供数据.
主要方法:
- 对190名静脉血栓栓塞和112名非膜性心房的患者进行了回顾性审计,这些患者转换为利瓦洛克萨班.
- 后续评估包括电话和面对面的采访,客观证实了COVID-19感染,出血和血栓形成.
- 在2020年4月至10月期间,患者接受了里瓦罗克萨班20毫克的治疗,平均为4个月.
主要成果:
- COVID-19感染率为3.3%,入院率为1.7%,与COVID-19相关的死亡率为0.7%.
- 没有发生重大出血事件;临床相关的非重大出血为0.7%,轻微出血为9.2%.
- 利瓦洛克萨班的出血率并不明显高于华法林;报告有一次肺栓塞和两次心肌梗塞.
结论:
- 在COVID-19大流行期间将患者从华法林转换为里瓦洛克萨班与可接受的安全性和有效性结果有关.
- 研究结果为在公共卫生危机期间的抗凝血管理提供了实用的见解.
- 这项研究为未来在类似紧急情况下的干预提供了信息.
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