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设计质量 (QbD) 开发基于Soluplus/TPGS的三元无形固体分散剂,以提高阿卡素的口服生物可用性

Jianghai He1, Yanyan Zhen2, Qian Chen3

  • 1Department of Gastroenterology, Wenzhou People's Hospital, The Third Affiliated Hospital of Shanghai University, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

Pharmaceutical development and technology
|December 11, 2025
PubMed
概括

这项研究开发了使用热挤出 (HME) 的阿卡素无形固体分散 (ASD),以提高口服生物可用性. 优化的配方显著提高了阿卡的溶解性和吸收性,证明HME是溶解不良药物的可扩展方法.

关键词:
在阿卡塞丁 (Acacetin) 中.生物可用性 生物可用性挤出 挤出 挤出 挤出热化的热化器固体分散的散发方式溶解度 溶解度 溶解度 溶解度

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