通过瘤微环境介导的活性氧物种生成,通过单原子纳米酶增强声动力疗法
Jing Yang1, Qing Ji1, Wenrong Zhu1
1Department of Medical Ultrasound, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Nanomedicine (London, England)
|December 11, 2025
概括
单原子纳米酶通过提高声敏剂效率和克服瘤缺氧来增强声动疗法 (SDT). 这种方法整合了精密瘤学的诊断和治疗,为先进的疗效平台铺平了道路.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 个性化精确瘤学需要综合诊断和治疗平台.
- 声动疗 (SDT) 使用超声波来激活声敏化剂,产生具有成像能力的瘤杀伤性反应性氧物种 (ROS).
- 目前的SDT面临的局限性是由于低效的声敏化剂,瘤缺氧和抗氧化剂防御.
研究的目的:
- 审查单原子纳米酶 (SAN) 的分子设计和催化机制,以增强SDT.
- 探索SAN如何克服SDT的局限性,例如瘤缺氧和抗氧化防御.
- 讨论基于SAN的声动力学剂的临床翻译的挑战和未来方向.
主要方法:
- 对SAN和SDT的文献进行系统审查.
- 分析SAN催化机制 (H2O2分解,谷甲耗尽,压电效应).
- 对SAN与声敏剂的整合进行评估,以减轻缺氧和图像导向治疗.
主要成果:
- SAN提供了原子级催化架构,以提高SDT的有效性.
- 抗氧化剂可以通过分解H2O2和耗尽谷氨来缓解瘤缺氧,以对抗抗氧化剂防御.
- 将SAN与声敏器集成,可以实现增强的,图像引导的精密疗法.
结论:
- SANs代表了一种通过解决关键局限性来增强SDT的转型战略.
- 基于SAN的声动力学剂对智能,安全和有效的癌症治疗有希望.
- 需要进一步的研究,以促进这些先进材料的临床翻译.
相关概念视频
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
01:46Electron Transport Chain: Complex I and II
18.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.4K
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K