肝病的严重程度与肝硬化心肌病相关:一项多中心研究
Xiaohan Ying1, Adesola O Oje2, Anton J De Witte3
1Weill Cornell Medicine, Division of Gastroenterology and Hepatology, New York, NY, USA.
概括
肝硬化心肌病 (CCM) 与等待肝移植的肝硬化患者的肝病严重程度有关. 早期发现CCM对于管理肝病并发症至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学 移植医学
背景情况:
- 肝硬化心肌病 (CCM) 是肝硬化患者的亚临床心脏功能障碍.
- CCM可能会加剧肝硬化并发症,如肝综合征-急性损伤 (HRS-AKI).
- 肝病严重程度与CCM特征之间的关联需要进一步描述.
研究的目的:
- 调查肝病严重程度与CCM存在之间的关联.
- 在肝硬化患者中识别与CCM相关的因素及其心声学特征.
- 在这个群体中探索CCM和HRS-AKI之间的关系.
主要方法:
- 在2015-2018年间接受肝移植 (LT) 的成年肝硬化患者的回顾性研究.
- 对LT前心声学研究进行分析,以确定CCM标记物.
- 多变量模型评估了肝病严重程度指数 (CTP,MELDNa),并发症和CCM存在/特征之间的关联.
主要成果:
- 在23%的患者中存在CCM.
- 中度至重度的炎和较高的MELDNa得分与CCM的存在有关.
- 肝脏疾病的严重程度 (MELDNa,CTP) 与特定的心声回声学CCM特征相关.
- CCM与HRS-AKI没有独立相关,尽管严重的肝病是.
结论:
- 肝病的严重程度与LT候选人的CCM存在和心声学特征有关.
- 结果可能有助于患者选择,并促进早期发现肝硬化中CCM.
- 对CCM在肝硬化并发症中的作用进行进一步研究是有必要的.
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