在一般人群中,C-反应蛋白和心血管风险
Berkan Kurt1, Martin Reugels1, Kai M Schneider2,3,4,5
1Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, Aachen D-52074, Germany.
European heart journal
|December 11, 2025
概括
高灵敏度C反应蛋白 (hsCRP) 有效预测没有已知的疾病的个体的心血管风险. 升高的hsCRP水平显著增加了主要不良心血管事件和死亡的风险,支持其在初级预防策略中的使用.
科学领域:
- 心血管医学 心血管医学
- 生物标志物研究 生物标志物研究
- 预防性心脏病学 预防性心脏病学
背景情况:
- 高灵敏度C反应蛋白 (hsCRP) 是一种已知的炎症标志物.
- 在没有确定的动脉样性心血管疾病 (ASCVD) 的个人中,hsCRP预测心血管 (CV) 风险.
- 评估hsCRP的临床相关性有助于其作为常规生物标志物用于残留风险识别的潜在使用.
研究的目的:
- 评估hsCRP在预测心血管事件方面的临床实用性.
- 确定hsCRP水平与主要不良心血管事件 (MACE),心血管死亡和全因死亡的关联.
- 评估hsCRP在初级心血管疾病预防中的作用.
主要方法:
- 基于人口的研究,使用英国生物银行数据.
- 在448,653名没有已知ASCVD的参与者中测量了hsCRP.
- 采用Cox的比例危险模型来分析与MACE,心血管死亡和任何原因死亡的关联.
主要成果:
- 与hsCRP>3 mg/L的人相比,hsCRP>3 mg/L的人患MACE的风险增加了34%,心血管和因任何原因死亡的风险显著增加,与hsCRP<1 mg/L的人相比.
- hsCRP水平≥2 mg/L与MACE风险增加22%,心血管风险和全因死亡风险增加有关.
- hsCRP在传统风险因素上表现出优越的预测性能,改进了SCORE2.2等风险预测模型.
结论:
- hsCRP是在没有已知的ASCVD的个体中进行CV事件的临床相关预测.
- 这些发现支持在初级预防中对hsCRP的常规评估.
- hsCRP有助于识别残留心血管风险的患者.
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