性差在心血管疾病风险和生物衰老速度的作用中的性别差异
Yufan Liu1, Chenglong Li2,3
1School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
European journal of preventive cardiology
|December 11, 2025
概括
生物衰老速度对心血管疾病 (CVD) 风险的性别差异作出了重大贡献. 监测衰老速度可以帮助解决心血管疾病的性别差距,并促进定制的预防策略.
科学领域:
- 心血管疾病研究研究
- 生物老龄化 生物老龄化
- 健康中的性别差异
背景情况:
- 心血管疾病 (CVD) 呈现出显著的性别差异,男性通常面临更高的风险.
- 导致这些心血管疾病风险性别差异的潜在生物机制尚不完全理解.
- 生物衰老与时间衰老不同,越来越多地被认为是影响健康结果的因素.
研究的目的:
- 研究生物衰老速度在解释心血管疾病 (CVD) 风险中的性别差异方面的作用.
- 量化生物衰老速度对男性和女性心脏病风险差异的贡献.
- 通过了解衰老的作用,探索针对性别特异性心血管疾病预防的潜在干预措施.
主要方法:
- 一项基于人口的研究,利用371,032名参与者的英国生物库数据.
- 使用两个关键指标评估生物衰老速度:表型衰老加速 (PhenoAgeAccel) 和端粒长度.
- 统计分析以比较心血管疾病风险,生物衰老速度以及男性和女性之间因衰老而解释的性别差异的比例.
主要成果:
- 与女性相比,男性在各种疾病 (任何心血管疾病,心房动,冠状动脉疾病,心力衰竭,中风) 中表现出更高的心血管疾病风险.
- 男人表现出比女性更快的生物衰老速度 (PhenoAgeAccel),生活方式,慢性疾病和代谢因素都有所贡献.
- 生物衰老速度显著解释了男性相关心血管疾病风险的大量比例 (60.4%-68.2%),这一发现在不同的衰老指标中一致.
结论:
- 生物衰老速度成为一个重要的因素,部分解释了心血管疾病风险中观察到的性别差异.
- 这些发现强调了监测生物衰老速度对于解决心血管疾病性别差距的重要性.
- 促进性别特定的CVD初级预防策略,以生物衰老为基础,至关重要.
关键词:
生物衰老 生物衰老心血管疾病是什么心血管疾病现型年龄 现型年龄性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异端粒长度 端粒长度 端粒长度更多相关视频
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