相关实验视频

Updated: Jan 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

人体前列腺组织中的TERT表达揭示了良性前列腺激增症进展中的潜在分子开关

Yajie Xu¹, Sheng Hu¹, Laurenz Berger¹

¹Department of Urology, LMU University Hospital, LMU Munich, Munich, Germany.

World journal of urology

|December 11, 2025

概括

端粒酶逆转录酶 (TERT) 表达在良性前列腺激增症 (BPH) 中很常见,并且与症状恶化和药物耐药性有关. 这表明TERT可能标志着针对性治疗的严重BPH表型.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
分子生物学分子生物学
在瘤学瘤学.

背景情况:

良性前列腺增生 (BPH) 是老年男性下泌尿道症状的常见原因.
端粒酶逆转录酶 (TERT) 在细胞衰老和组织重塑中发挥作用.
以前的研究表明TERT在遗传和零星BPH中的参与.

研究的目的:

研究TERT表达在人类BPH中的作用.
检查BPH患者TERT表达和临床参数之间的关联.
探索TERT表达与光滑肌肉受体和增殖标志物的相关性.

主要方法:

100名BPH患者的前列腺组织的RT-PCR分析,这些患者接受了激光取核.
对TERT阳性和TERT阴性患者之间的临床参数进行比较.
对TERT表达与收缩平滑肌肉受体 (例如α1A-上腺受体,内甲蛋白受体) 和Ki67的相关性分析,并与前列腺癌组织进行比较.

主要成果:

在81%的BPH样本中检测到TERT mRNA.
有TERT阳性患者的症状得分较高,尿液余量增加.
TERT表达与α1A-受体,内甲蛋白受体A和B,血栓素受体,血栓素合成酶和Ki67.7相关联. 与前列腺癌组织相比,BPH组织中的TERT表达显着更高.

结论:

在BPH中,TERT表达与症状严重程度增加和潜在的药物耐药性有关.
TERT可以作为一个分子标志物,用于更严重的BPH表型.
针对TERT驱动的BPH病理的有针对性的干预措施是可能的.

关键词:

良性前列腺增生症 (BPH) 是一种遗传性 BPH 的遗传性全基因组关联研究 (GWAS)下尿路症状 (LUTS) 是指下尿路的症状.端粒酶逆转录酶 (TERT) 的使用虚无的症状虚无的症状

更多相关视频

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...