微生物失生症和宿主微生物相互作用在增殖性白性白血病:洞察致癌的潜在潜力
Bruno Špiljak1, Petar Ozretić2, Vlaho Brailo1,3
1Department of Oral Medicine, University of Zagreb School of Dental Medicine, Gundulićeva 5, Zagreb, 10000, Croatia.
Archives of microbiology
|December 11, 2025
概括
微生物失调,口腔微生物组的不平衡,在增殖性白血病 (PVL) 的进展中起着关键作用,这是一个具有侵略性的口腔潜在恶性疾病. 这种口腔微生物组的转变可能与其他因素协同作用,为PVL诊断和治疗提供新的途径.
科学领域:
- 口腔病理学 口腔病理学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 增殖性白血病 (PVL) 是一种罕见的,积极的口腔潜在恶性疾病 (OPMD),具有恶性转变的高风险.
- 人们还不完全了解PVL的病因,但最近的研究强调了口腔微生物组在其进展中的重要作用.
- 微生物失生症的特点是微生物多样性和生态平衡的改变,创造了一个有利于表皮细胞变化的促炎环境.
研究的目的:
- 综合PVL微生物基础上的当前知识.
- 探索宿主微生物相互作用在与PVL相关的口腔致癌发生中的作用.
- 确定未来的研究方向,以了解PVL病原体和开发有针对性的干预措施.
主要方法:
- 对PVL,口腔白血病,OPMD,口腔微生物组和口腔状细胞癌研究的文献综述.
- 从1985年到2025年在PubMed和Web of Science数据库中进行的搜索.
- 在PVL中综合了与微生物种类,生物膜形成,免疫调节和宿主微生物交叉交叉相关的发现.
主要成果:
- 像Fusobacterium和Porphyromonas这样的特定口腔种类通过生物膜形成和免疫逃避与PVL病原发生有关.
- 微生物失生症有助于慢性炎症微环境,促进上皮细胞的转变.
- 像元基因组学和多基因组学集成等先进的方法对于揭示PVL失生机制至关重要.
结论:
- 微生物失生症不是PVL的唯一原因,但可能与遗传,表观遗传和免疫因素相互作用.
- 了解PVL的口腔微生物组为生物标志物发现和新的治疗策略提供了潜力.
- 对口腔微生物组的研究可能会导致更早的PVL诊断和微生态向干预措施的开发.
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