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发现异印林-2(1H) - 碳胺STING抑制剂作为抗炎剂

Xiaoqian Zhou1,2,3, Shumin Zang4,5, Shanyan Yao1

  • 1Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China.

Molecular diversity
|December 11, 2025
PubMed
概括

研究人员开发了新型的异因多林-2(1H) - 碳胺STING抑制剂. 化合物3b强烈抑制STING,抑制免疫路径,并在急性损伤模型中显示有效性.

关键词:
抑制剂是一种抑制剂.这种类型的物质是异印二 (Isoindoline-2) 1H) 碳酸胺.这就是为什么SAR SAR SAR.干扰素基因的刺激剂.

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