臭氧治疗作为癌症患者MRONJ的辅助策略:系统性审查和元分析
Mailon Cury Carneiro1, Júlia França da Silva1, Tiago Carvalho Dos Santos1
1Department of Surgery, Stomatology, Pathology, and Radiology, Bauru School of Dentistry, University of São Paulo. Alameda Octávio Pinheiro Brisolla 9-75, Bauru, 17012-901, SP, Brazil.
概括
臭氧疗法对与药物相关的下骨硬化 (MRONJ) 有潜在的益处. 需要进一步进行高质量的试验,以确认其在MRONJ支持性护理中的有效性.
科学领域:
- 口腔外科和瘤外科.
- 再生医学是一种再生医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与药物相关的下骨硬化 (MRONJ) 是抗吸收和抗血管原性癌症疗法的严重并发症.
- 目前对MRONJ的管理策略存在局限性,需要探索新的支持性治疗方法.
- 以抗微生物和再生性质而闻名的臭氧疗法是MRONJ管理的潜在候选者.
研究的目的:
- 系统地审查和元分析臭氧疗法作为治疗药物相关的骨硬化 (MRONJ) 的辅助治疗的临床疗效.
- 评估在被诊断为MRONJ的成年患者中臭氧治疗的综合成功率和报告的结果.
主要方法:
- 根据PRISMA 2020指南进行了系统审查和元分析.
- 在多个数据库 (PubMed,Embase,Scopus,Web of Science,Cochrane Library) 和灰色文献中进行了搜索.
- 包括6项涉及178名患者的临床研究,并使用随机效应模型对比例进行了元分析.
主要成果:
- 在MRONJ研究中,臭氧治疗的综合临床成功率为71% (95% CI:55%-84%),具有中等的异质性.
- 经常观察到的好处包括改善疼痛和生活质量,没有报告的不良影响.
- 所有纳入的研究都被认为具有低偏差风险.
结论:
- 臭氧疗法可能在治疗与药物相关的骨瘤治疗中提供临床益处.
- 目前支持臭氧治疗MRONJ的证据由于研究的局限性和异质性而具有非常低的确定性.
- 高质量的随机临床试验和标准化方案对于确定臭氧治疗在MRONJ支持性护理中的最终作用至关重要.
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