在学术医疗中心使用凝血因子VIIa的现实世界经验
Alyssa R George1, Katelyn W Sylvester2, Dareen M Kanaan2
1Department of Pharmacy, Henry Ford Hospital, Detroit, MI, USA.
概括
医院可以通过将eptacog alfa转换为eptacog beta,这是一个重组因子VIIa (rFVIIa) 剂,从而大大节省成本. 这种药物使用评估没有发现任何不良事件,并避免了大量的成本,支持潜在的替代.
科学领域:
- 血液学 血液学 血液学
- 药物经济学 药物经济学
- 临床药房 临床药房
背景情况:
- 艾普塔科格α和艾普塔科格β是用于治疗血友病A或B的复合因子VIIa (rFVIIa) 药物,并配有抑制剂.
- 这项研究评估了从eptacog alfa到eptacog beta作为机构首选的rFVIIa产品的过渡.
研究的目的:
- 审查eptacog alfa和eptacog beta的使用情况.
- 评估转换为eptacog beta.产生的成本节约.
主要方法:
- 从2023年10月到2024年9月的rFVIIa行政部门的回顾性图表审查.
- 评估产品选择,剂量和不良事件 (血栓,新出血,治疗升级).
- 使用批发采购成本计算的成本节约.
主要成果:
- 在17名患者的27次rFVIIa管理中,77.8%的患者使用了eptacog beta.
- 指示包括血友病出血 (44.4%),手术前管理 (33.3%),心脏手术 (11.1%),和抗凝固逆转 (11.1%).
- 没有发生血栓事件;在12个月内,估计避免成本为554,400美元.
结论:
- 在一小群患者中安全使用eptacog beta,没有任何不良结果.
- 医院可以考虑评估他们的rFVIIa使用情况,以寻找潜在的替代机会.
- 转换为eptacogβ证明了显著的成本避免和有效利用.
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