在儿童癌症幸存者中,随后发生的脑膜瘤
Daniel C Bowers1, Table Cooney2,3, Yan Chen4
1Division of Pediatric Hematology/Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, Dallas.
JAMA network open
|December 11, 2025
概括
儿童癌症幸存者有很大的患脑膜瘤的风险,特别是在部放射治疗后. 这项研究强调,由于发病率和死亡率增加,需要对高风险人群进行查.
科学领域:
- 神经瘤学神经瘤学
- 儿科瘤学 儿科瘤学
- 癌症生存率研究的研究.
背景情况:
- 儿童癌症幸存者面临长期的健康风险,包括脑膜瘤等二次瘤.
- 在这个人群中,与脑膜瘤相关的发病率,风险因素和死亡率尚未完全理解.
研究的目的:
- 为了确定儿童癌症幸存者的脑膜瘤发病率.
- 为了确定脑膜瘤发展的新风险因素.
- 为了表征多重脑膜瘤和脑膜瘤.
- 描述脑膜瘤诊断后因特定原因死亡率.
主要方法:
- 对24886名儿童癌症幸存者进行了回顾性队列研究,这些儿童癌症幸存者在1970-1999年间被诊断出患有癌症.
- 脑膜瘤是自我报告,并通过病理学报告确认.
- 包括化疗,辐射剂量和人口统计等风险因素被抽象.
主要成果:
- 诊断后35年内膜瘤的累积发病率为2.3%.
- 更高的风险与头骨辐射,年轻的诊断年龄,女性性别和特定的化疗 (白金,6 - 默卡普托普林,内治疗) 有关.
- 在非西班牙裔黑人幸存者和那些接触化剂的人群中观察到较低的风险. 脑膜瘤诊断后的5,10年和15年的死亡率分别为4.9%,10.5%和18.4%.
结论:
- 脑膜瘤在儿童癌症幸存者中发生了显著的发病率和死亡率.
- 部放射治疗和某些化疗剂是显著的危险因素.
- 这些发现支持了对高风险幸存者群体中脑膜瘤查的潜在益处.
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