疫苗接种引发的皮病 (rubra pilaris) 是由于疫苗接种引起的
Cristiana Colonna1, Nicola A Monzani2, Alice Moiraghi1
1Pediatric Dermatology Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Italian journal of dermatology and venereology
|December 11, 2025
概括
皮病 (Pityriasis rubra pilaris,简称PRP) 是一种罕见的皮肤疾病,可以由疫苗接种引发,特别是在接受SARS-CoV-2疫苗的成年人中. 早期识别这种关联对于有效的患者管理和治疗至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 皮病 (Pityriasis rubra pilaris,简称PRP) 是一种罕见的炎症性斑块状皮肤病,其病因不明.
- 虽然感染是常见的触发因素,但疫苗接种很少被报告为潜在的原因.
- 了解潜在的疫苗相关的PRP触发因素对于患者护理至关重要.
研究的目的:
- 系统地审查疫苗接种引发的Pityriasis rubra pilaris (PRP) 记录的病例.
- 分析疫苗接种后的PRP的特征和结果.
- 强调在PRP诊断中考虑疫苗接种史的重要性.
主要方法:
- 在PubMed和Scopus上对2000年1月至2024年6月期间发表的文章进行了系统的文献搜索.
- 搜索的重点是疫苗接种后发生的PRP病例.
- 另外一个未公布的案例被纳入了分析.
主要成果:
- 从23篇文章中确定了30个疫苗接种后PRP病例.
- 大多数受影响的个体是成年男性 (66.6%),中位数发病年龄为55岁.
- 大多数病例 (90%) 发生在SARS-CoV-2疫苗接种后,主要使用mRNA疫苗 (51.9%); 46.6%发生在第一剂后,66%的重新接种疫苗的人经历了恶化.
- 儿科病例涉及麻疹 - 疹 - 风疹和疹 - 疹 - 咳疫苗.
- 疫苗接种后PRP的发病通常发生在接种后10天的中位数内.
- 这种情况通常对治疗反应良好,只有13.3%的病例没有得到解决.
结论:
- 接种疫苗后的皮病 (Pityriasis rubra pilaris,简称PRP) 很少见,但可能被诊断不足.
- 认识到疫苗接种和PRP发作之间的关联对于识别潜在触发因素很重要.
- 包括最近接种疫苗在内的全面病史对于诊断和管理PRP至关重要.
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