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Updated: Jan 7, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

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希斯甲基转移酶KMT2D是血统可塑性和治疗反应的关键调解者,用于割抵抗性前列腺癌的治疗反应

Srushti Kittane1, Erik Ladewig2, Taibo Li3

  • 1Johns Hopkins University Baltimore United States.

Cancer research
|December 11, 2025
PubMed
概括

基隆甲基转移酶KMT2D在前列腺癌的进展中起着至关重要的作用. 将KMT2D与PI3K/AKT通路一起定位可能为割抵抗性前列腺癌 (CRPC) 亚型提供新的组合疗法.

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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