内脏脂肪指数与慢性阻塞性肺病之间的关联:横截面分析
Shaofeng Zhang1,2,3,4,5, Yidan Lin6, Zekui Fang4
1Department of Respiratory and Critical Care Medicine, The first College of Clinical Medicine Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, Hubei, China.
Science progress
|December 11, 2025
概括
较高的内脏肥胖指数 (VAI) 水平与慢性阻塞性肺病 (COPD) 风险增加有关. 这项研究表明,VAI可能有助于早期发现COPD,并对高危人群进行风险分层.
科学领域:
- 代谢健康 代谢健康
- 肺部医学 肺部医学
- 流行病学 流行病学
背景情况:
- 怀疑肥胖会使慢性阻塞性肺病 (COPD) 症状恶化.
- 早期发现COPD对于有效治疗和改善患者治疗结果至关重要.
- 内脏脂肪指数 (VAI) 是一种用于评估内脏脂肪积累的新型代谢生物标志物.
研究的目的:
- 调查内脏肥胖指数 (VAI) 与慢性阻塞性肺病 (COPD) 患病率之间的关联.
- 测试该假设,即高的VAI水平独立地与患上COPD的风险更高有关.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (1999-2018,2021-2023) 的横截面分析.
- 使用多变量后勤回归模型来评估VAI-COPD关系.
- 进行了子组分析,平滑曲线拟合和值效应分析以完善研究结果.
主要成果:
- 在16167名参与者中,观察到VAI水平和COPD患病率之间存在显著的正相关性.
- 经过调整以考虑混因素后,这种关联仍然很重要.
- 调整曲线分析显示,VAI的值效应为2.55,表明COPD风险增加的临界水平.
结论:
- 较高的内脏肥胖指数 (VAI) 与较高的慢性阻塞性肺病 (COPD) 患病率显著相关.
- 这些发现表明,VAI评估可能对COPD高风险个体的初始风险分层有价值.
- 进一步的研究可能会探索VAI在治疗容易患上COPD的人群中的临床实用性.
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