泛性皮囊性牛皮会增加皮肤病的风险:第一种基于人口的证据
概括
泛性性牛皮 (GPP) 显著增加了患上皮肤质性病 (PG) 的风险. 这项研究强调了需要提高临床意识和对GPP患者PG的监测.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 泛性性牛皮 (GPP) 和皮肤质 (PG) 是一种罕见的,严重的中性恋性皮肤病.
- 这些情况共享重叠的自身炎症途径,表明潜在的联系.
- 之前的病例报告表明了GPP-PG关联,但缺乏基于人口的数据.
研究的目的:
- 量化患有泛性性牛皮 (GPP) 的患者患上皮肤质性牛皮 (PG) 的风险.
- 为了比较PG的风险在GPP患者与非GPP牛皮患者和对照.
- 提供基于人口的证据,证明GPP和PG之间的关联.
主要方法:
- 使用TriNetX电子健康记录网络 (2018-2023) 的回顾性队列研究.
- 确定的成年人患有GPP (ICD10 L40.1) 和非GPP牛皮 (L40.0-L40.9不包括L40.1).
- 1:1倾向分数匹配年龄,性别,种族和自身免疫性疾病;对PG发病率的生存分析 (L88).
主要成果:
- 与对照组相比,GPP患者的PG风险明显高 (HR 5.14).
- 非GPP牛皮患者的PG风险也比对照患者高 (HR 3.83).
- GPP与PG比非GPP牛皮的风险更大 (HR 2.33).
结论:
- 这项研究提供了第一个基于人口的证据,即GPP显著增加了PG风险.
- 与对照组和其他类型的牛皮相比,GPP患者患PG的风险要高得多.
- 研究结果强调需要加强临床警和针对GPP患者的PG的有针对性的监测.
更多相关视频
02:28Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
734
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
705
相关概念视频
Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Peptic Ulcer Disease I: Introduction
711
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
711
Peripheral Artery Disease I: Introduction
288
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
288
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
1.1K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.1K
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
