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在小鼠中,疼痛灵敏度的调节由位点coeruleus-paraventricular-thalamic核-前带皮质前带皮质通路进行

Shihui Kuai¹, Zijie Li², Ziyi Wu¹

¹Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

|December 11, 2025

概括

这项研究揭示了一条分层的疼痛途径,涉及部 (locus coeruleus,LC),准腹腔体 (paraventricular thalamus,PVA) 和前带皮层 (anterior cingulate cortex,ACC). 这种LC-PVA-ACC电路通过北上腺素 (NE) 信号调节疼痛敏感性.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
神经生物学神经生物学神经生物学

背景情况:

从部 (locus coeruleus,LC) 到 thalamus 和前带皮层 (anterior cingulate cortex,ACC) 的 noradrenergic 投射与疼痛行为有关.
这些LC投射在疼痛处理中的等级组织仍然不清楚.

研究的目的:

为了研究LC衍生型的上腺素 (NE) 输入到副腹腔的胸膜核 (PVA) 和ACC如何差异调节感觉敏感.
为了阐明LC-PVA-ACC电路在疼痛调节中的等级组织.

主要方法:

在小鼠中使用完整的弗洛恩德辅助剂 (CFA) 诱导炎症性疼痛.
结合Fos-TRAP,体内记录和病毒追踪来绘制功能连接的地图.
对LC投射的光遗传和化学遗传操纵,以评估对神经活动和疼痛行为的影响.

主要成果:

在LC,PVA和ACC中,CFA增加了c-Fos表达和神经活动.
确定了单突触LC-ACC和多突触LC-PVA-ACC电路,与 nociception 相关的LC神经元优先投射到PVA.
与直接LC-ACC刺激相比,LC-PVA-ACC电路的激活引起了更强的ACC发射和触觉反应,并产生了更大的疼痛敏感度调节.

结论:

这条LC-PVA-ACC通路代表了一个层次性的noradrenergic电路,调节可感知敏感性.
这一途径利用甲状腺皮层中继器来处理疼痛.
揭示了LC-NE系统调节疼痛的电路特定机制.

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