肠道微生物组和丁酸盐区分了克洛斯特里迪奥伊德难治殖和儿童感染的情况
Maribeth R Nicholson1, Siyuan Ma2, Britton A Strickland2
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
The Journal of infectious diseases
|December 11, 2025
概括
肠道微生物组和丁酸盐水平在患有无症状Clostridioides difficile定居和症状感染的儿童之间有所不同. 这些差异可能在发展Clostridioides difficile感染症状中起作用.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
背景情况:
- 困难菌感染 (CDI) 导致严重的疾病,但无症状的殖民也会发生.
- 毒素本身不能区分CDI和儿童无症状殖民.
- 其他因素,如肠道微生物群和代谢物,可能会影响CDI的发展.
研究的目的:
- 研究患有CDI和无症状殖民的儿童之间的肠道微生物组和丁酸盐水平的差异.
- 识别与症状性CDI相关的微生物和代谢因素与殖民.
主要方法:
- 一项病例对照研究比较了55名患有症状的CDI的儿童和50名患有C. difficile的无症状儿童.
- 用16S rRNA测序分析了便样本以确定微生物组合.
- 用液体染色学质谱法量化酸盐水平.
主要成果:
- 症状性CDI与改变的肠道微生物丰富度密切相关,包括增加的Escherichia/Shigella和Haemophilus,以及减少的Faecalibacterium和Bifidobacterium.
- 在症状CDI的儿童中,与无症状殖民的儿童相比,观察到微生物丁酸盐生产者和便丁酸盐的耗尽.
- 在区分CDI状态时,肠道微生物群组成的差异比临床因素更为显著.
结论:
- 在无症状的C. difficile殖民和儿童的症状CDI之间,肠道微生物群和丁酸盐水平存在显著差异.
- 这些微生物和代谢变化表明在症状性CDI的发病过程中可能发挥作用.
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