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在光滑肌的功能丧失作为肌性缩的模型,与胃肠动性相关的MBNL

Janel A M Peterson1,2, Jesus A Frias1, Andrew N Miller1

  • 1Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.

Proceedings of the National Academy of Sciences of the United States of America
|December 11, 2025
PubMed
概括

肌性失调1型 (DM1) 由于MBNL蛋白质的损失导致胃肠 (GI) 功能障碍,导致光滑肌肉过度活跃. 针对胃肠道收缩活性的疗法可以缓解DM1胃肠道症状.

关键词:
替代性拼接是一种替代性的拼接.胃肠道运动不稳定.像肌肉盲人一样的肌肉盲人肌性发育不良症 肌性发育不良症顺滑肌肉是指平滑的肌肉.

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