相关实验视频

Updated: Jan 8, 2026

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

胆汁酸缺乏症将 perfluorooctane sulfonate 诱导的氧化压力介导的脂肪肝与骨关节炎联系在一起

Jialing Yu¹, Sihan Huang¹, Jianbin Zhang¹

¹State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive molecules and Discovery of Innovative Drugs, Jinan University; National Engineering Research Center of Genetic Midicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangdong provincial Biotechnology Drug & Engineering Technology Research Center, Jinan University Guangzhou 510632, China; Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Journal of hazardous materials

|December 11, 2025

概括

暴露于 perfluorooctane sulfonate (PFOS) 会通过诱导肝脏氧化应激和破坏肠道微生物群而导致骨关节炎. 阿斯丁 (AX) 有效地逆转PFOS诱导的关节损伤和脂肪肝疾病.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
分子生物学分子生物学

背景情况:

perfluoroalkyl物质 (PFAS) 是一种持续性环境污染物.
PFAS对关节健康的影响在很大程度上是未知的.
之前的研究将环境污染物与关节损伤联系起来.

研究的目的:

研究 perfluorooctane sulfonate (PFOS) 对关节健康的影响.
阐明PFOS引起的关节损伤的潜在机制.
探索PFOS诱导的骨关节炎 (OA) 的潜在治疗策略.

主要方法:

斑马鱼模型暴露于PFOS.
对肝脏氧化应激,胆酸代谢和肠道微生物群的分析.
探究冠状细胞中的FXR和GLP-1R信号通路.
评估阿斯塔山丁 (AX) 作为治疗剂.

主要成果:

暴露于PFOS诱导了斑马鱼门的骨关节炎.
PFOS导致肝脏氧化应激,减少胆酸合成,并导致脂质积累.
PFOS改变了肠道微生物群的组成,可能降低了二次胆酸.
胆酸缺乏与有限的FXR和GLP-1R激活在胆红细胞中有关,促进OA.
通过吸收活性氧物种 (ROS),阿斯丁 (AX) 治疗逆转了PFOS诱导的OA和肝肥胖症.

结论:

通过涉及肝脏氧化应激和胆汁酸失调的机制,PFOS是一种强大的骨关节炎诱导剂.
肠道微生物群的破坏和随后的胆酸不足有助于PFOS引起的关节损伤.
向ROS是一种有前途的治疗策略,用于PFOS诱导的骨关节炎.

关键词:

胆酸是什么意思胆酸是什么意思非酒精性脂肪性肝病是非酒精性脂肪性肝病.骨关节炎是一种骨关节炎.氧化应激是一种氧化应激.perfluorooctane 硫酸盐的使用情况

更多相关视频

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

相关概念视频

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...