γ-氨基黄油酸改善了肠-大脑轴功能和低蛋白饮食下 brojlers 的行为适应
Randi Randi1, Anisa Aulia1, Muhtadin Muhtadin1
1Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Poultry science
|December 11, 2025
概括
低粗蛋白 (CP) 饮食与γ-氨基黄油酸 (GABA) 补充剂没有影响肉的生产力,但调节了基因表达和行为. 在养低CP饮食的 brojlers 中,GABA改善了肠道屏障功能和免疫反应.
科学领域:
- 动物科学动物科学
- 禽类的营养 养
- 肠道健康 肠道健康
背景情况:
- 低粗蛋白 (CP) 饮食提高了料效率,并减少了 brojler 生产中的氨排放.
- 然而,降低的CP可能会对肉生产率,免疫功能和肠道完整性产生负面影响.
- γ-氨基黄油酸 (GABA) 是一种非蛋白质氨基酸,对动物健康和新陈代谢有潜在的益处.
研究的目的:
- 为了评估低CP饮食中GABA补充剂对 brojler生产力,酶活性,神经类基因表达和行为的影响.
- 研究GABA的潜力,以减轻与减少饮食CP相关的负面影响.
- 了解GABA对肉生理和行为影响的分子机制.
主要方法:
- 参与360只雄性罗斯308肉的因数实验使用两个CP水平 (19.5%和18.0%) 和三个GABA水平 (0,100和200毫克/公斤) 进行.
- 评估了生产力,酶活性 (氨酶,蛋白酶),神经皮性和炎症性基因表达 (RT-qPCR) 和肉行为.
- 进行了统计分析,以确定CP,GABA及其对测量参数的相互作用的影响.
主要成果:
- 饮食中的CP和GABA水平并没有显著影响肉的整体生产力.
- 降低CP下调的抗炎和紧结基因表达,同时改变肉的行为.
- 加巴补充剂上调氧化基因,下调无氧化基因,增强抗炎和紧结基因表达,调节肉的行为,促进食和饮用.
结论:
- 在不损害肉生产的情况下,可以减少1.5%的食CP,但会影响肠道屏障和炎症基因表达.
- 在低CP饮食中补充GABA有效地促进稳态调节,改善免疫和肠道屏障功能,并积极调节肉行为.
- 作为料添加剂,GABA在低蛋白养策略下显示有前途,以支持肉的健康和性能.
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