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病原性传染性支气管炎病毒可以诱导十二指肠炎症和Hy-Line棕色的屏障缺陷

Chenlu Feng¹, Bingqing Zhang¹, Cheng Huang¹

¹Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Poultry science

|December 11, 2025

概括

病原性传染性支气管炎病毒 (NIBV) 损害了的十二指肠,增加了分泌IgA并引起炎症. 这项研究显示,NIBV会损害肠道的物理,化学和免疫障碍,影响家禽的肠道健康.

科学领域:

禽类的健康禽类的健康
病毒学病毒学
免疫学免疫学免疫学

背景情况:

病原性传染性支气管炎病毒 (NIBV) 通常影响家禽,造成脏,呼吸道和肠道损伤.
尽管肠道是主要的免疫器官,但NIBV对肠道损伤的研究不足.
了解NIBV对十二指肠屏障的影响对于家禽健康管理至关重要.

研究的目的:

为了研究NIBV感染对子十二指肠道屏障功能的影响.
在NIBV接种疫苗后,分析十二指肠中的组织病理变化和细胞因子表达.

主要方法:

Hy-Line棕色被分为对照组和感染NIBV的组.
NIBV SX9被注射到疾病组中的28天大的母中.
十二指肠组织被分析为本体病理学,SIgA含量和屏障相关细胞因子的表达.

主要成果:

尼布病毒感染导致十二指肠出血斑点,并增加了分泌IgA (SIgA) 水平.
组织病理学揭示了小的高度下降,加大了密室深度,减少了杯状细胞.
NIBV降低了物理 (ZO-1,奥克卢丁,克劳丁-1) 和化学 (MUC2,TFF3) 障碍基因的调节,同时提高了与免疫相关的细胞因子 (IL-2,IL-4,IL-17,TGF-β,TNF-α,CCR7) 的调节.

结论:

尼布病毒在的十二指肠中复制,诱导炎症并损害肠道屏障功能.
十二指肠的物理,化学和免疫障碍受到NIBV感染的损害.
在家禽中,NIBV感染显著影响十二指肠正常功能.

关键词:

化学障碍物是一种化学障碍物.十二指肠 (Duodenum) 是指十二指肠的一个部分.免疫障碍物免疫障碍物神经病原性传染性支气管炎病毒物理障碍物是一种物理障碍.

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