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Updated: May 11, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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解读生物启发的脂质基尼尔卡宾的抗Mycobacterium结核病活性

Jon Bouvet1, Chérine Mehalla2, Maria Vieira de Brito3

  • 1Université de Toulouse, Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), CNRS (UMR 5068), 118 route de Narbonne, Toulouse Cedex 9, F31062, France; Université de Toulouse, CNRS, Laboratoire de Chimie de Coordination, 205 route de Narbonne, Toulouse Cedex 4, F31077, France.

European journal of medicinal chemistry
|December 11, 2025
PubMed
概括

研究人员探索了猎醇.

关键词:
乙烯脂类脂类是什么 乙烯脂类这是一种抗菌性抗菌素.福尔卡林迪奥尔 (Falcarindiol) 是一种类型的生物.结核病菌菌菌的结核病菌的结核病菌.结构与活动的关系.

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...