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mRNA COVID-19 疫苗与同时或顺序注射的非活化流感疫苗的免疫性:一项随机临床试验

Emmanuel B Walter¹, Elizabeth P Schlaudecker², Kawsar R Talaat³

¹Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA; Duke Human Vaccine Institute, Durham, North Carolina, USA.

|December 11, 2025

概括

与mRNA COVID-19和流感疫苗同时接种疫苗并没有削弱免疫反应. 这一发现支持这些重要的公共卫生疫苗的同时使用.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

当与流感疫苗一起使用时,研究了mRNA COVID-19疫苗免疫性潜在的削弱.
美国的一项多站点试验评估了同步与顺序管理.

研究的目的:

为了确定mRNA COVID-19疫苗和流感疫苗的联合使用是否会影响免疫性.
在同时或连续接种疫苗后评估SARS-CoV-2抗体水平.

主要方法:

年龄≥5岁的参与者接受了四价同源无活化流感疫苗 (IIV4) 或安慰剂与mRNA COVID-19疫苗.
抗体标位 (SARS-CoV-2伪病毒中和) 在基线和接种疫苗后28天被测量.
组包括同时给予和顺序给予 (IIV4在mRNA COVID-19疫苗接种7-14天后).

主要成果:

在D614G菌株 (p=0.79) 和BA.4/5变种 (p=0.69) 的同步和顺序组之间,在接种疫苗后的SARS-CoV-2抗体标位上没有显著差异.
D614G的几何平均标位为4357.1 (同时) 和4492.3 (顺序).
BA.4/5的几何平均标位为1547.8 (同时) 和1463.8 (顺序).

结论:

同时使用mRNA COVID-19和流感疫苗不会减弱免疫性.
这些发现支持同时使用这些疫苗.
临床试验.gov 标识:NCT05028361.gov 临床试验.gov 标识:NCT05028361.

关键词:

免疫性免疫性免疫性不活化的流感病毒疫苗.这是mRNA-COVID-19疫苗.

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