在社区卫生中心的HIV阴性MSM和TW中,HCV感染,风险因素和PrEP使用
Àngel Rivero1, Albert Dalmau-Bueno2, Félix Pérez3
1BCN Checkpoint - Projecte dels NOMS-HISPANOSIDA, Spain; Fundació Lluita Contra les Infeccions, Badalona, Spain; University Hospital Germans Trias i Pujol, Infectious Diseases Unit, Badalona, Spain.
Journal of infection and public health
|December 11, 2025
概括
在巴塞罗那,与男性发生性关系的HIV阴性男性 (MSM) 和跨性别女性 (TW) 之间的C型肝炎病毒 (HCV) 感染率很低,而不考虑HIV暴露前预防 (PrEP) 的使用. 感染个体的风险行为较高,需要进一步研究.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 性健康 性的健康
背景情况:
- 性传播的C型肝炎病毒 (HCV) 感染是与男性发生性关系的男性 (MSM),特别是艾滋病毒感染者的担忧.
- 关于HIV阴性MSM中HCV感染率的数据有限,特别是那些使用HIV暴露前预防 (PrEP) 的MSM.
- 之前的研究并没有系统地选PrEP使用者和不使用者的HCV.
研究的目的:
- 评估HIV阴性MSM和跨性别女性 (TW) 中HCV感染的流行率.
- 为了比较PrEP用户和非PrEP用户之间的HCV患病率.
- 在这个人群中识别与HCV感染相关的行为风险因素.
主要方法:
- 在巴塞罗那的一家社区性健康中心向艾滋病毒阴性MSM和TW提供了点照顾的HCV查 (血清学和/或PCR).
- 使用日志-二项式模型,根据性行为和药物使用行为估计HCV流行率.
- 进行描述性分析,将HCV感染与PrEP使用和行为模式联系起来.
主要成果:
- 为13089人提供HCV查,其中包括3039名PrEP使用者.
- 在PrEP使用者 (0.10%) 和非PrEP使用者 (0.12%) 中,HCV患病率低且相似.
- 确定了一例急性HCV感染病例;在TW中没有发现任何病例. 冲击,群体性,注射器共享,拳击和化学性使用药物与HCV感染有关.
结论:
- 在参加社区中心的HIV阴性MSM和TW中观察到活跃的HCV感染的低患病率.
- 虽然感染HCV的个体 (PrEP和非PrEP用户) 表现出更高的风险行为,但低患病率使这些发现具有探索性.
- 需要进行更大规模的分析研究来证实这些关联,并为有针对性的预防策略提供信息.
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