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Updated: Jul 21, 2026

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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多omics分析识别了潜在的表观遗传位点,与不同人群的肌缩性侧面硬化症的生存相关

Yuqi Gu1, Yan Chen2, Xuelin Tang3

  • 1Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Centre), Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai, China; State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

EBioMedicine
|December 11, 2025
PubMed
概括

这项研究揭示了BAG6 cg27014438甲基化作为一种关键的表观遗传修饰剂,影响了阿米托罗菲侧面硬化症 (ALS) 的存活率. 遗传变异调节这种甲基化,影响ALS的进展和患者的结果.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.表观基因组学是指表观基因组学.基因组学就是基因组学.幸存的生存方式

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