身体工作要求和风险的类风湿性关节炎,全身性硬化症和全身性红斑狼. 丹麦的一项纵向队列研究
Helena Breth Nielsen1, Nidhi Gupta1, Astrid Juhl Andersen1
1The National Research Centre for the Working Environment, Copenhagen, Denmark.
Journal of autoimmunity
|December 11, 2025
概括
更高的体力劳动要求与男性的风湿性关节炎 (RA) 风险增加有关,但与女性无关. 与全身性硬化症 (SSc) 和全身性红斑狼 (SLE) 的关联也在男性中观察到,在女性中发现的结果不一致.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 物理工作需求是重要的职业暴露.
- 类风湿性关节炎 (RA),全身性硬化症 (SSc) 和全身性红斑狼 (SLE) 是慢性自身免疫性疾病.
- 了解职业暴露与这些疾病之间的联系对于公共卫生至关重要.
研究的目的:
- 调查体力劳动要求与发展RA,SSc和SLE的风险之间的关联.
- 为了检查这些协会分别对男性和女性.
主要方法:
- 全国范围内,基于登记册的队列研究丹麦超过210万个人.
- 利用工作暴露矩阵 (JEM) 来评估最近,累积和长期的体力工作需求.
- 使用波桑回归来估计RA,SSc和SLE的发病率比率 (IRR) 从1997年到2018年.
主要成果:
- 在高体力劳动要求的职业中,男性患RA,SSc和SLE的风险增加.
- 妇女没有表现出RA风险增加;SSc的结果不一致,并且观察到SLE风险降低.
- 更高的累积和长期的体力劳动需求与男性的RA风险增加有关.
结论:
- 身体工作的要求与男性的RA风险较高有关,可能SSc和SLE程度较低.
- 对于女性来说,在RA方面没有发现任何显著的关联,在SSc和SLE方面存在不一致或反向的关联.
- 这些发现突出了自身免疫性疾病的潜在性别特异性职业风险.
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