相关实验视频
Updated: Jan 8, 2026
10:10
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
13.0K
癌症相关认知障碍患者非药物干预措施的影响:元分析
Zeyin Xin1, Jiaming Li1, Yibin Hu1
1Beijing University of Chinese Medicine, Beijing, China.
International journal of nursing studies
|December 11, 2025
概括
几种非药物疗法在改善癌症幸存者的认知功能方面表现有前途. 然而,证据质量各不相同,需要个性化治疗方法和进一步的研究.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 康复 康复 康复 康复
背景情况:
- 与癌症相关的认知障碍 (CRCI) 是影响幸存者的生活质量的普遍问题.
- 通常使用非药理疗法,但它们对CRCI的比较有效性尚未得到充分证实.
研究的目的:
- 系统地审查和元分析随机对照试验 (RCT),评估CRCI的非药物干预措施.
- 评估不同干预措施对主观和客观认知结果的有效性.
主要方法:
- 搜索了多个数据库 (PubMed,科学网络,EMBASE,Cochrane,CNKI,SinoMed) 截至2025年2月.
- 包括60个RCT和5129名参与者,将干预措施分为基于CBT的认知训练,认知训练,体育活动,正念,多模式和针.
- 使用随机效应模型汇集治疗效应,计算标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 基于认知行为疗法的干预措施,身体活动和基于正念的干预措施显著改善了主观认知 (SMD:0.53-0.86).
- 基于认知行为疗法的干预,认知训练,基于正念的干预和针治疗显示出客观认知的显著改善 (SMD:0.48-1.23).
- 对于大多数结局,在研究中发现了实质性的异质性.
结论:
- 有证据表明,多种非药物干预可以提高癌症幸存者的认知能力.
- 高异质性和证据的低确定性需要谨慎的解释.
- 建议将干预措施量身定制为个体需求,并进行更大规模,精心设计的试验.
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
512
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
512
01:22Alzheimer's Disease: Treatment
752
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
752
01:29Nursing Interventions II: Selecting and Classifying the Nursing Interventions
3.0K
Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
3.0K
01:15Drug Dosing: Geriatric Patients
209
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
209
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
175
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
175