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相关概念视频

Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

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The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
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Sympathetic Division of the ANS01:19

Sympathetic Division of the ANS

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The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
3.2K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

2.5K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
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Sympathetic Signaling01:31

Sympathetic Signaling

2.1K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
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Parasympathetic Division of the ANS01:08

Parasympathetic Division of the ANS

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The parasympathetic division of the autonomic nervous system (ANS) regulates rest and digestion functions in the body. It works in opposition to the sympathetic division, promoting relaxation, conservation of energy, and digestion. The parasympathetic division consists of preganglionic fibers originating from specific cranial nerves (III, VII, IX, X) and the sacral spinal nerves (S2-S4). These fibers synapse with postganglionic neurons in the terminal ganglia, innervating various organs and...
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The Sympathetic Nervous System01:25

The Sympathetic Nervous System

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Overview
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相关实验视频

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Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
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Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

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交感功能单元被遗传定义后质神经元编码.

Yaru Wei1, Zongya Ma1, Boyan Zhang1

  • 1Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Fudan University Shanghai, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Center for Clinical Neuro-AI, Fudan University, Shanghai 200032, China.

Neuron
|December 11, 2025
PubMed
概括

研究人员发现了两种不同的交感神经元类型控制器官功能. 一种类型调节肠道运动,而另一种类型控制血管收缩,揭示了自主控制的"标记线"系统.

关键词:
自主神经系统自主神经系统结核-上层中肠腺.肠-大脑相互作用同情的功能单位.同情神经系统的同情神经系统.

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Location, Dissection, and Analysis of the Murine Stellate Ganglion
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Location, Dissection, and Analysis of the Murine Stellate Ganglion

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Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
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Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing

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Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
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Location, Dissection, and Analysis of the Murine Stellate Ganglion
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Location, Dissection, and Analysis of the Murine Stellate Ganglion

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Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
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Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing

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科学领域:

  • 神经科学是一个神经科学.
  • 自主神经系统研究 自主神经系统研究
  • 分子生物学分子生物学

背景情况:

  • 交感神经系统通过复杂的途径调节内部器官的功能.
  • 对于交感通路的具体组织和功能,人们的理解有限.

研究的目的:

  • 为了识别和表征在乳上层介质 (CG-SMG) 内的同情神经元的不同亚群.
  • 阐明这些神经元子群体在控制器官生理学的特定功能作用.

主要方法:

  • 利用遗传标记技术来区分神经元群体.
  • 进行单细胞转录组分析以确定分子特征.
  • 进行功能操纵以评估生理反应.

主要成果:

  • 确定了两个分子上不同的CG-SMG神经元子群:Calb2-阳性和Nxph4-阳性.
  • 阳性神经元投射到胃肠道的肌肉层,调节肠道的运动.
  • Nxph4阳性神经元刺激血管,充当控制血液流动的内脏血管收缩剂.

结论:

  • 交感神经系统采用"标记线"逻辑,不同的神经元子集独立控制特定器官功能.
  • 这一发现提供了对自主神经系统组织和控制机制的精细理解.