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从内生菌真菌Phomopsis sp.中获得的Dimeric Phthalides是一种内生菌真菌. 的一个Aconitum carmichaelielieli

Yuan Gao¹, Jia-Hui Wang¹, Ming-Qian Han¹

¹Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China.

|December 11, 2025

概括

来自真菌Phomopsis sp.的新二次性甲酸. 被从Aconitum carmichaeli中分离出来的. 一些化合物显示出适度的抗真菌活性对病原性真菌,如Candida albicans.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药用植物研究药用植物研究

背景情况:

居住在药用植物中的内菌是新型生物活性化合物的丰富来源.
众所周知,Phomopsis物种可以产生各种具有潜在药理活动的二次代谢物.
Aconitum carmichaeli是一种传统的药用植物,具有很长的使用历史.

研究的目的:

从内生菌真菌Phomopsis sp.中分离和表征新的二次性甲酸. 在 YM 355364.4.
评估分离化合物的抗菌活性对病原性微生物.
探索与Aconitum carmichaeli相关的真菌内菌的化学多样性.

主要方法:

使用色谱技术分离和净化真菌代谢物.
使用广泛的NMR光谱,HRESIMS和DP4+计算来阐明新化合物的结构.
使用微稀释方法进行抗菌活性评估,以确定最小抑制度 (MIC).

主要成果:

确定了三种新的二次性甲酸,称为 (±) -phomophthalides A-C ((±) -1-3),以及八种已知的化合物.
化合物1对Fusarium solani,Candida albicans和Botrytis cinerea (MICs 16-32μg/mL) 显示出中度的抑制活性.
化合物2对B. cinerea和C. albicans表现出抗真菌活性 (MICs为16-32μg/mL).

结论:

植物内的真菌 Phomopsis sp. 这种真菌从Aconitum carmichaeli中分离出来的YM 355364,可以产生新的二度甲酸.
隔离的化合物具有显著的抗微生物特性,特别是对抗真菌病原体.
这项研究强调了来自药用植物的内菌的潜力,作为发现新抗菌剂的来源.

关键词:

艾康尼图姆·卡米歇尔 (英语:Aconitum carmichaelielieli) 是一个名为阿科尼图姆的卡米歇尔.这是一种内性真菌.菲莫普西斯 (Phomopsis sp.) 是一种植物.类化物类化物

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