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Updated: Jan 8, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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Published on: November 9, 2020

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利用针对G蛋白结合受体的向蛋白质降解:CCR2分子降解剂的发展

Khaled Essa1, Natalia V Ortiz Zacarías1, Sascha Roth2

  • 1Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden 2333 CC, The Netherlands.

Journal of medicinal chemistry
|December 11, 2025
PubMed
概括

研究人员开发了针对G蛋白结合受体 (GPCRs) 的新型分子降解剂,特别是CC化学因子受体2 (CCR2). 一种化合物LUF7996有效降解了CCR2并抑制了单细胞迁移,为新的GPCR向治疗铺平了道路.

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