相关实验视频

Updated: Jan 8, 2026

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

利用天生的免疫系统:一种针对CD47和CD24的新型双特异性抗体,用于选择性瘤清除

Lidi Nan¹, Liandi Chen², Weifeng Huang³

¹School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Journal for immunotherapy of cancer

|December 11, 2025

概括

一种针对CD47和CD24的新型双特异性抗体显示出癌症免疫治疗的前景. 这种新药物通过阻断"不要吃我"信号来增强抗瘤活性,同时与现有的CD47疗法相比提高了安全性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
生物技术是生物技术.

背景情况:

与瘤相关的巨细胞 (TAMs) 对于抗瘤免疫至关重要,但通常被瘤免疫抑制.

研究的目的:

开发一种针对CD47和CD24的新型双特异性抗体,以克服目前基于CD47的治疗方法的局限性.
为了设计一种具有改进瘤向,Fc效应器功能和安全概况的抗体.

主要方法:

酵母显示和人类单克隆抗体生成针对针对CD47和CD24的vHHs.
在小鼠模型中进行了体外表征和体内疗效和安全性评估.
探索潜在的机制和瘤微环境的变化.

主要成果:

鉴定了针对CD47的强有力的联体阻断性vHHs和针对CD24的人类抗体.
开发一种双特异性抗体 (BiAb-103C),可以抑制CD47-SIRPα相互作用,并调解Fc-effector功能.
在临床前模型中证明了抗瘤活性和有利的安全概况.

结论:

反CD47/CD24双特异性抗体为癌症免疫治疗提供了一个有前途的治疗策略.
这种方法解决了与CD47向剂相关的疗效和安全问题.
对于那些对现有的免疫疗法没有反应的患者来说,这是潜在的治疗选择.

关键词:

抗体是对抗体的一种.免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.巨细胞是一个巨细胞.

更多相关视频

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...