患有唐氏综合征和睡眠呼吸障碍的儿童的心血管并发症
Wiktoria Gocal1, Katarina Zeder2, Bradley A Maron2
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Paediatric respiratory reviews
|December 11, 2025
概括
患有唐氏综合征 (DS) 和睡眠呼吸障碍 (SDB) 的儿童表现出心肺功能障碍. 早期检测和多模式治疗对于降低这一群体心血管风险至关重要.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 睡眠医学 睡眠医学
- 遗传学 是一个遗传学.
背景情况:
- 唐氏综合征 (DS) 的儿童有解剖学和神经肌肉的差异增加睡眠呼吸障碍 (SDB) 的风险.
- 儿童的SDB可能导致严重的心血管并发症.
研究的目的:
- 进行对DS和SDB儿童心血管并发症的范围审查.
- 为了确定未来的研究和临床实践的知识差距.
主要方法:
- 按照PRISMA-ScR指南进行系统的范围审查.
- 在Embase,Scopus和MEDLINE数据库中进行搜索.
- 包括专注于儿童 (1-18岁) 的DS和SDB报告心血管结果的研究.
主要成果:
- 分析了7项涉及1437名参与者的研究.
- 患有DS和SDB的儿童表现出自主反应,心率受损和血压下降,缺氧增加.
- 观察到左心室扩张性功能障碍和双心室重塑的早期迹象.
结论:
- SDB,DS和心肺末端器官功能障碍之间存在联系,表明临床风险较高.
- 持续的心脏监测和先进的生理措施是必不可少的.
- 多模式呼吸道阻塞治疗可以减轻长期的心血管风险.
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