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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Polygenic Traits01:18

Polygenic Traits

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Epistasis Analysis01:09

Epistasis Analysis

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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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相关实验视频

Updated: Jan 8, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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同表达范围的关联研究将基因调节的相互作用与复杂的特征联系起来.

Mykhaylo M Malakhov1, Wei Pan2

  • 1Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Nature communications
|December 11, 2025
PubMed
概括
此摘要是机器生成的。

引入共同表达全局关联研究 (COWAS),一种新方法,用于找到与复杂特征相关的基因和蛋白质对. 牛牛 (COWAS) 揭示了相互作用的蛋白质如何影响疾病,即使他们单独行动时也不会.

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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相关实验视频

Last Updated: Jan 8, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

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科学领域:

  • 遗传学和系统生物学 系统生物学
  • 计算生物学 计算生物学
  • 疾病风险预测 疾病风险预测

背景情况:

  • 转录组和蛋白质组范围的关联研究 (TWAS/PWAS) 确定与疾病风险相关的基因/蛋白质.
  • 现有的方法忽略了基因或蛋白质之间的共同表达和相互作用效应.
  • 了解分子网络对于复杂的特征遗传学至关重要.

研究的目的:

  • 介绍共同表达全局关联研究 (COWAS) 方法.
  • 识别具有与复杂特征相关的遗传调节共同表达的基因/蛋白质对.
  • 研究蛋白质与蛋白质相互作用在疾病病因学中的作用.

主要方法:

  • 牛 (COWAS) 训练模型来预测基因变异的表达和共同表达.
  • 测试假定的共同表达和特征之间的关联,考虑直接影响.
  • 将该方法应用于英国生物银行的血蛋白质组数据.

主要成果:

  • 确定了数十种相互作用的蛋白质对,与胆固醇水平,阿尔茨海默氏症和帕金森病相关.
  • 证明蛋白质共同表达可以影响复杂的特征,独立于单个蛋白质效应.
  • 展示了COWAS在分子网络中解开直接和相互作用效应的能力.

结论:

  • 牛提供了一种新的方法来发现与复杂特征相关的基因调节的共同表达模式.
  • 由COWAS揭示的蛋白质与蛋白质相互作用为疾病机制提供了新的见解.
  • 该方法增强了对调解疾病遗传影响的分子网络的理解.