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A B 细胞-IgA-上皮轴增强抗瘤免疫力,改善HPV相关的阴茎状细胞癌的结果

Tao Tao¹, Lianbang Zhu², Deyun Shen¹

¹Department of Urology, The First Affiliated Hospital of USTC, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Nature communications

|December 11, 2025

概括

人类乳头瘤病毒 (HPV) 阳性阴茎癌显示免疫细胞活性增加. 在这些患者中,B细胞-IgA-PIGR通路增强了抗瘤免疫力和生存率.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病毒学病毒学

背景情况:

阴茎状细胞癌 (PSCC) 是一种罕见但具有攻击性的癌症.
人类乳头瘤病毒 (HPV) 感染是约50%PSCC病例的关键驱动因素,通常与更好的患者结果有关.

研究的目的:

在阴茎癌中研究瘤微环境 (TME) 的细胞景观.
阐明免疫细胞和特定分子途径在HPV相关的PSCC中的作用.

主要方法:

单细胞RNA测序是在23名未经治疗的PSCC患者的瘤微环境细胞上进行的.
这些发现在85名PSCC患者的更大队列中得到了验证.
使用IgA缺乏的小鼠进行了功能性研究.

主要成果:

PSCC表现出显著的免疫细胞透,特别是在HPV阳性瘤中.
阳性HPV瘤显示B细胞,血细胞,三级淋巴体结构和IgA分泌的水平较高.
阳性HPVPSCC中的恶性细胞表达聚合IgA受体 (PIGR),促进IgA转细胞和抗瘤反应.
过度表达PIGR增强了瘤亡和免疫反应,这种效应在IgA缺乏的小鼠中减少.
升高的IgA和PIGR水平与改善的患者存活率相关.

结论:

这项研究提供了PSCC TME.的单细胞地图.
B细胞-IgA-PIGR轴是驱动抗瘤免疫和HPV阳性PSCC的临床结果的关键因素.

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