糖尿病持续时间,血糖控制和中风和中风亚型风险:全国性的前性队列研究
Xiang Gao1, Huan-Huan Yang2, Fei Xie3
1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Scientific reports
|December 11, 2025
概括
糖尿病持续时间较长和血糖控制较差会增加中风风险. 延长糖尿病持续时间和高HbA1c水平的结合显著增加了全中风和缺血性中风的风险.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 糖尿病是一种日益严重的全球健康问题.
- 脑卒中是全球残疾和死亡的主要原因之一.
- 了解糖尿病人群中风风险因素对于预防至关重要.
研究的目的:
- 调查糖尿病持续时间和血糖控制与中风风险之间的关联.
- 检查这些因素对缺血性中风和出血性中风亚型的影响.
- 探索糖尿病持续时间和血糖控制与中风风险相关的潜在相互作用.
主要方法:
- 利用了来自英国生物库 (UK Biobank) 的数据,这是一个基于人口的英国成年人队列.
- 包括23,401名患有糖尿病的成年人,没有先前的中风史.
- 采用多变量Cox模型来评估发生中风的关联,平均随访时间为11.6年.
主要成果:
- 糖尿病持续时间较长与总中风,缺血性中风 (IS) 和出血性中风 (HS) 的风险增加相关.
- 较高的糖化血红蛋白 (HbA1c) 水平与较高的总中风和IS风险有关,但不是HS.
- 观察到一种显著的相互作用:糖尿病持续时间长 (≥15年) 和血糖控制不良 (HbA1c ≥8.0%) 个体的总和缺血性中风风险显著增加.
结论:
- 长时间的糖尿病持续时间和低于最佳的血糖控制都是中风的独立风险因素,特别是缺血性中风.
- 糖尿病持续时间长和血糖控制不良的联合存在协同增强了中风风险.
- 这些发现强调了长期糖尿病管理和血糖控制对预防中风的重要性.
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