对阿育吠陀配方Rasasindura的药理学和毒理学见解
Sushant U Kamath1,2, Kayalvizhi Rajendran1,2, Brindha Pemiah1,3
1School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, 613 401, India.
Scientific reports
|December 11, 2025
概括
阿拉维达制剂Rasasindura (RS) 在老鼠治疗剂量时没有毒性,通过改善精子数量和运动性,有效治疗小精子症. 较高剂量可能会引起神经效应,需要医疗监督.
科学领域:
- 艾尔韦达医学是一种医药.
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 全球存在关于传统药物中毒性的担忧.
- 拉萨辛布拉 (RS) 是一种阿育吠陀草药金属制剂,需要对其安全性和有效性进行评估.
- 寡精症是男性不孕症的一个重要因素,需要新的治疗方法.
研究的目的:
- 评估Rasasindura (RS) 的毒理学和药理学.
- 评估RS在小精子症中的治疗潜力.
- 研究含有的阿育吠陀配方的安全性.
主要方法:
- 在Wistar大鼠的体内毒理研究中,给予治疗性和高剂量的RS.
- 主要器官 (大脑,肝脏,脏,丸) 的组织病理学和生物化学分析.
- 在使用RS的小精子诱导的瑞士阿尔比诺小鼠中进行治疗研究,其中包括基因表达分析 (Catsper,Calpain) 和微阵列研究.
主要成果:
- 在治疗剂量和高剂量的老鼠中,RS没有显著的器官,血液学或生物化学毒性,在高剂量的老鼠中只观察到轻微的过度活跃.
- 组织病理学证实主要器官或丸中没有形态或功能异常.
- 在与通道激活相关的小鼠中,RS显著改善了精子数量,运动性,并减少了小精子诱导的异常.
- 微阵列分析表明潜在的抗炎,抗肥胖,抗糖尿病,抗癌和免疫调节活性,以及与毒性相关的某些基因表达.
结论:
- 纯化含的阿育吠陀药物如RS在正确使用时,在治疗度下是安全的.
- RS在小精子症治疗中显示出显著的治疗前景.
- 较高度的RS可能会带来神经风险,这强调了对强效金属制药的医疗监督的需要.
更多相关视频
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
1.9K
07:58Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
796
相关概念视频
01:27Effects of Chemicals: Overview
1.9K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.9K
01:28Structure-Activity Relationships and Drug Design
1.6K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.6K
01:19Pharmacovigilance
1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K
01:18Additional Routes of Drug Administration
4.6K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.6K
01:13Therapeutic Index
6.4K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.4K
01:25Dose-Response Relationship: Selectivity and Specificity
9.5K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
9.5K