在精神分裂型人格障碍和精神分裂症的工作记忆表现期间异常有效的连接:一种频谱方法
Erin A Hazlett1,2,3, Vincenzo G Fiore4, Keith M Shafritz5,6
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. erin.hazlett@mssm.edu.
精神分裂症谱系障碍中的工作记忆缺陷涉及改变的大脑连接. 健康的个体在增加任务负载时表现出脊髓-ACC连接,与表现出逆转的脊髓-ACC连接的精神分裂症患者不同.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 工作记忆 (WM) 缺陷是精神分裂症的核心特征.
- 精神分裂性人格障碍 (SPD) 是一种与较不严重的WM障碍相关的疾病.
- 了解精神分裂症谱系障碍中的网络动态,可以了解风险和弹性.
研究的目的:
- 调查在精神分裂症频谱内的工作记忆任务期间,在前额 - 双肩网络内有效连接的变化.
- 为了比较健康对照 (HC),SPD患者和精神分裂症患者的网络动态.
主要方法:
- 动态因果建模 (DCM) 用于分析功能连接.
- 参与者 (N=105) 完成了一项N-back任务,工作内存负载不同.
- 评估了侧面前额叶皮层 (lPFC),前额皮层 (ACC) 和顶层皮层 (PC) 之间的有效连接.
主要成果:
- 工作内存负载调节ACC-PC连接在不同组的不同.
- 健康的对照组显示出体与ACC的连接性,而精神分裂症患者则显示出逆转的ACC与体的连接性.
- 精神分裂型人格障碍表现出一种中间或混合的联系模式.
结论:
- 由工作记忆负载调节的典型的顶膜-ACC有效连接在精神分裂症频谱中受到干扰.
- 异常的连接模式,特别是涉及到ACC,可能是精神分裂症谱系障碍的认知缺陷和症状严重性的基础.
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