你的大脑看起来没有一天超过70岁! 在认知完整的老年人中,与大脑预测年龄的横截面关联
Mark K Britton1,2,3, Hannah Hoogerwoerd4,5, Joshua Juhasz4
1Department of Epidemiology, University of Florida, Gainesville, FL, 32610, USA. mark.britton@yale.edu.
GeroScience
|December 11, 2025
概括
由于生存效应,认知完整的最老的成年人对典型的大脑衰老风险因素表现出弹性. 大脑预测的年龄差异与这个群体的认知无关,这表明认知储备很高.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 大脑衰老研究研究
背景情况:
- 在年轻人群中确定的脑衰老风险因素可能不适用于认知完整的老年人 (85岁以上) 由于生存效应.
- 了解大脑的维护和认知储备在极端衰老中至关重要.
研究的目的:
- 为了评估与衰老相关的风险因素和脑预测年龄差异 (brainPAD) 之间的关联,在认知完整的老年人中.
- 评估 brainPAD 和认知表现之间的关系,以了解大脑维护与认知储备之间的关系.
主要方法:
- 对206名年龄在85-99岁之间的认知完好成年人的横截面研究.
- 使用T1加权的MRI扫描来使用brainageR工具生成脑PAD.
- 收集了关于生活方式,病史和药物使用的自我报告数据;用标准化电池评估认知功能.
主要成果:
- 与男性相比,女性的脑衰老延迟明显多 (p=0.002).
- 没有其他测试的风险因素 (例如,教育,吸烟,BMI,病史) 与脑PAD有显著的关联.
- 在这个样本中,BrainPAD与任何认知性能指标没有显著的关联.
结论:
- 认知完整的老年人似乎异常耐受常见的衰老风险因素,可能是由于生存偏见.
- 大脑预测的年龄差异在解释这种有弹性的老年人群的认知表现方面具有有限的实用性,可能反映出大量的认知储备.
- 幸存者效应显著影响了老年人中大脑衰老研究的发现.
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