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基于模型的比较,对固定剂量杜洛特格拉维尔治疗方案的剂量减少策略进行了比较

Laura Dickinson1, Laura Else1, Willem D F Venter2

  • 1Centre for Experimental Therapeutics, University of Liverpool, Liverpool, UK.

The Journal of antimicrobial chemotherapy
|December 12, 2025
PubMed
概括

降低诺福维尔迪索普罗克西尔-胺-多卢特格拉维尔 (TLD) 的剂量可以在短缺期间保持供应. 建模表明剂量降低策略,如4天,休息3天 (4:3) 显著降低低治疗目标以下的多卢特格拉维尔水平.

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