Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Precise Cancer Anti-acid Therapy Monitoring Using pH-Sensitive MnO<sub>2</sub>@BSA Nanoparticles by Magnetic Resonance Imaging.

ACS applied materials & interfaces·2021
Same author

Effects of histone H4 hyperacetylation on inhibiting MMP2 and MMP9 in human amniotic epithelial cells and in premature rupture of fetal membranes.

Experimental and therapeutic medicine·2021
Same author

Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health.

Cell & bioscience·2021
Same author

Diluted-CdS Quantum Dot-Assisted SnO<sub>2</sub> Electron Transport Layer with Excellent Conductivity and Suitable Band Alignment for High-Performance Planar Perovskite Solar Cells.

ACS applied materials & interfaces·2021
Same author

A microporous surface containing Si<sub>3</sub>N<sub>4</sub>/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration.

Bioactive materials·2021
Same author

Clinical importance of ADC in the prediction of <sup>125</sup>I in the treatment for gliomas.

Journal of Cancer·2021
Same journal

Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

Endothelial injury with capillary leak: A final common pathway in acute AAV toxicity?

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

Long-term functional synaptic integration of genome-edited retinal organoids in a primate model of macular degeneration.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

Nox1/4 inhibitor Setanaxib treatment ameliorates cardiac function in mouse models of Duchenne Muscular Dystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

HSP90α-USP7-DNMT1 Axis Drives Hepatocellular Carcinoma Recurrence After Microwave Ablation by Disrupting ACSS3-Mediated Propionate Metabolism.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
查看所有相关文章

相关实验视频

Updated: Jan 8, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.7K

通过CAR-T细胞疗法重新定义多发性硬化症

Yan-Ruide Li1, Yuning Chen1, Lili Yang2

  • 1Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Molecular therapy : the journal of the American Society of Gene Therapy
|December 12, 2025
PubMed
概括
此摘要是机器生成的。

化学抗原受体 (CAR) -T细胞疗法通过向自身免疫反应,显示出治疗多发性硬化症 (MS) 的前景. 需要进一步的研究来优化长期疾病控制的安全性和有效性.

关键词:
在CAR-T细胞疗法中.针对CD19的CAR-T是我们的目标.在CRS中,您可以使用CRS.在MSMSMSMSMSMSMSMSMSMSMS中,我们可以看到自身免疫性疾病 自身免疫性疾病自主反应的B细胞.细胞因子释放综合征 细胞因子释放综合征多发性硬化症 多发性硬化症神经毒性的作用.

更多相关视频

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.8K
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

22.0K

相关实验视频

Last Updated: Jan 8, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.7K
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.8K
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

22.0K

科学领域:

  • 神经免疫学 神经免疫学
  • 细胞疗法细胞疗法
  • 自身免疫性疾病 自身免疫性疾病

背景情况:

  • 多发性硬化症 (MS) 是一种慢性中枢神经系统自身免疫性疾病,导致神经系统逐渐衰弱.
  • 目前的多发性硬化疗法只能提供有限的缓解,无法扭转现有的损害.
  • 化学抗原受体 (CAR) -T细胞疗法在瘤学中取得了成功,正在成为MS等自身免疫性疾病的潜在治疗方法.

研究的目的:

  • 审查应用CAR-T细胞治疗多发性硬化症的最新进展.
  • 讨论在神经免疫学中CAR-T细胞治疗的挑战和未来方向.
  • 探索CAR-T细胞在MS中实现长期疾病控制的潜力.

主要方法:

  • 对多发性硬化症中CAR-T细胞治疗的临床前研究和早期临床试验的综述.
  • 分析从CAR-T细胞在瘤学和其他自身免疫性疾病中的应用中吸取的经验教训.
  • 讨论优化抗原点和最大限度地降低毒性的策略.

主要成果:

  • 针对CD19+B细胞的CAR-T细胞疗法在针对自身免疫疾病的临床前和早期临床研究中显示出令人鼓舞的疗效,包括MS.
  • 这种方法具有选择性消除自身反应性免疫细胞的潜力,为免疫系统重置提供了一条途径.
  • 仍然存在重大挑战,包括毒性管理,持续的治疗效益和可扩展的临床实施.

结论:

  • 卡尔-T细胞疗法代表了管理多发性硬化症的一个有希望的前沿,可能提供持久的缓解和逆转病理.
  • 克服抗原选择,安全和制造方面的挑战对于将CAR-T细胞疗法转化为MS的标准临床实践至关重要.
  • 进一步的研究和临床试验至关重要,以建立CAR-T细胞作为神经免疫学中的变革性治疗方法.